function disable()
{
document.getElementById("mySelect").disabled=true
}
function enable()
{
document.getElementById("mySelect").disabled=false
}
<form> <select id="mySelect"> <option>苹果</option> <option>桃子</option> <option>香蕉</option> <option>桔子</option> </select> <br> <br> <input type="button" onclick="disable()" value="禁用列表"> <input type="button" onclick="enable()" value="启用列表"> </form>